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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-25
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pubmed:abstractText |
Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
569-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12713420-Acetylene,
pubmed-meshheading:12713420-Alkynes,
pubmed-meshheading:12713420-Animals,
pubmed-meshheading:12713420-Fatty Acids, Unsaturated,
pubmed-meshheading:12713420-Inhibitory Concentration 50,
pubmed-meshheading:12713420-Japan,
pubmed-meshheading:12713420-Matrix Metalloproteinases, Membrane-Associated,
pubmed-meshheading:12713420-Metalloendopeptidases,
pubmed-meshheading:12713420-Molecular Structure,
pubmed-meshheading:12713420-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:12713420-Oxidation-Reduction,
pubmed-meshheading:12713420-Porifera,
pubmed-meshheading:12713420-Protease Inhibitors,
pubmed-meshheading:12713420-Stereoisomerism
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pubmed:year |
2003
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pubmed:articleTitle |
Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata.
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pubmed:affiliation |
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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