Linked Life Data

12713097

Source:http://linkedlifedata.com/resource/pubmed/id/12713097

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-4-25
pubmed:abstractText
Acid-initiated ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) was conducted under microwave irradiation (MI) at 2.45 GHz. At this frequency, metallic catalysts were no longer necessary. The effects of microwave power, irradiation time, epsilon-CL: acid molar ratio and acidity of acid on the polymerization were investigated. Both the rate of polymerization and the molar mass of polymer obtained were enhanced in comparison with conventional thermal method. Poly(epsilon-caprolactone) (PCL) with weight-average molar mass (Mw) over 12000 g/mol and Mw/Mn below 1.6 was synthesized in the presence of carboxylic acids such as maleic acid (MA), succinic acid (SA) and adipic acid (AA). The polymerization was also carried out when the monomer contained a certain amount of ibuprofen (IBU), by which, the IBU-PCL controlled release system was prepared directly. The release of IBU from the system was sustained from 12 h to 9 days with IBU content in weight increasing from 5 to 20%. It seems that this is a promising method to prepare drug controlled release systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-5063
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-53
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Acid-initiated polymerization of epsilon-caprolactone under microwave irradiation and its application in the preparation of drug controlled release system.
pubmed:affiliation
Department of Polymer Science, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't