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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-4-24
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pubmed:abstractText |
The study was undertaken to investigate the 5-HT receptor mediating the inhibitory effect of 5-HT on peristalsis in the guinea-pig isolated ileum. The facilitatory and inhibitory effects were measured as the decrease and increase, respectively, in the intraluminal pressure required to trigger peristalsis. In the presence of 5-HT(2/3&4) receptor antagonists ketanserin (0.1 micro M), granisetron (1 micro M) and SB-204070 (1 micro M), a cumulative addition (0.1-100 micro M) of 5-HT or 5-carboxamidotryptamine, but not 2-methyl-5-HT produced a concentration-dependent increase in the threshold required to trigger peristalsis. The 5-HT(7) receptor selective antagonist SB-269970-A (0.01-1 micro M) or methiothepin (0.01-0.1 micro M) concentration-dependently antagonised this response to 5-HT. SB-269970-A (1 micro M) and methiothepin (1 micro M) were also able to restore peristalsis in tissues in which peristalsis was inhibited by a prior addition of 30 micro M of 5-HT. The results indicate an involvement of 5-HT(7) receptors in the inhibitory effect of 5-HT on peristalsis in the guinea-pig ileum.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-10051134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-10556917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-10664612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-10669560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-10744088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-10821781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-11293643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-11414657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-11693255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-13429484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-1346162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-1364818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-6662198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-7664814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-8306103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-8566121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-9149537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12711620-9401783
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-methyl-5-HT,
http://linkedlifedata.com/resource/pubmed/chemical/5-carboxamidotryptamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxanes,
http://linkedlifedata.com/resource/pubmed/chemical/Granisetron,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/SB 204070A,
http://linkedlifedata.com/resource/pubmed/chemical/SB 269970,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 7 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1210-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12711620-Animals,
pubmed-meshheading:12711620-Dioxanes,
pubmed-meshheading:12711620-Dose-Response Relationship, Drug,
pubmed-meshheading:12711620-Granisetron,
pubmed-meshheading:12711620-Guinea Pigs,
pubmed-meshheading:12711620-Ileum,
pubmed-meshheading:12711620-Ketanserin,
pubmed-meshheading:12711620-Peristalsis,
pubmed-meshheading:12711620-Phenols,
pubmed-meshheading:12711620-Piperidines,
pubmed-meshheading:12711620-Receptors, Serotonin,
pubmed-meshheading:12711620-Serotonin,
pubmed-meshheading:12711620-Sulfonamides
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pubmed:year |
2003
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pubmed:articleTitle |
5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum.
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pubmed:affiliation |
Bradford School of Pharmacy, University of Bradford, Bradford BD7 1DP. B.R.Tuladhar@bradford.ac.uk
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pubmed:publicationType |
Journal Article,
In Vitro
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