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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-4-24
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pubmed:abstractText |
Fibrinogen is one of the acute-phase proteins whose levels are elevated during periodontal disease. Recent studies suggest that excessive fibrinogen production might play a role in upregulating host immune responses. In addition, there is a relationship between the -455G/A polymorphism (HaeIII) in the 5' flanking region of the beta-fibrinogen gene promoter and increased fibrinogen levels. In this study, we investigated the distribution of the -455G/A polymorphism and the relationship of this specific genotype to fibrinogen levels in periodontitis patients.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3492
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-37
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12710752-5' Flanking Region,
pubmed-meshheading:12710752-Adenine,
pubmed-meshheading:12710752-Age Factors,
pubmed-meshheading:12710752-Aged,
pubmed-meshheading:12710752-Alleles,
pubmed-meshheading:12710752-Analysis of Variance,
pubmed-meshheading:12710752-Case-Control Studies,
pubmed-meshheading:12710752-Chronic Disease,
pubmed-meshheading:12710752-Confidence Intervals,
pubmed-meshheading:12710752-Female,
pubmed-meshheading:12710752-Fibrinogen,
pubmed-meshheading:12710752-Genotype,
pubmed-meshheading:12710752-Guanine,
pubmed-meshheading:12710752-Homozygote,
pubmed-meshheading:12710752-Humans,
pubmed-meshheading:12710752-Male,
pubmed-meshheading:12710752-Middle Aged,
pubmed-meshheading:12710752-Odds Ratio,
pubmed-meshheading:12710752-Periodontitis,
pubmed-meshheading:12710752-Polymorphism, Genetic,
pubmed-meshheading:12710752-Promoter Regions, Genetic,
pubmed-meshheading:12710752-Sex Factors,
pubmed-meshheading:12710752-Smoking
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pubmed:year |
2003
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pubmed:articleTitle |
Association of increased levels of fibrinogen and the -455G/A fibrinogen gene polymorphism with chronic periodontitis.
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pubmed:affiliation |
Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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