Linked Life Data

12709805

Source:http://linkedlifedata.com/resource/pubmed/id/12709805

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-4-23
pubmed:abstractText
The results of treating primary subglottic carcinoma (PSC) with radiation or surgery are disappointing, and recurrent disease is common. The purpose of this study was twofold: first, to present our experience of treating two multifocal patients with PSC and second, to report our treatment results using two different clinical treatment sequences. Between September 1991 and June 2002, we treated five patients with primary squamous cell carcinoma of the subglottis at the Tri-Service General Hospital, Taipei, Taiwan. It constitutes 5.2% of all 96 laryngeal cancers. Two patients were treated with primary surgery and planned postoperative radiation, and two patients were treated with primary radiation and salvage surgery. The fifth patient was treated with radiation alone. At the time of follow-up, four patients were alive without evidence of disease at 58 months, 28 months, 20 months and 11 months, respectively. One patient (T2N0) died of mediastinal lymph node and liver metastasis 2.5 years after being treated with primary surgery and postoperative radiation. In conclusion, our findings revealed that primary radiation in combination with salvage surgery resulted in a better survival rate than primary surgery with planned postoperative radiation. Primary surgery with postoperative radiation was unable to control the multifocal characteristics and occult mediastinal lymphatic drainage. It is important to point out that due to the small sample size and variation in cancer stages, analyses and conclusions regarding two different treatment sequences were not statistically feasible.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0937-4477
pubmed:author
pubmed:issnType
Print
pubmed:volume
260
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Multifocal carcinoma of the larynx presenting as subglottic carcinoma.
pubmed:affiliation
Department of Otolaryngology and Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Kung Road, NeiHu, Taipei, Taiwan. wfs19582001@yahoo.com.tw
pubmed:publicationType
Journal Article