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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-4-23
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pubmed:abstractText |
The locus coeruleus-noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states, in part through the actions of noradrenergic beta-receptors in the medial septal (MS) and medial preoptic (MPOA) areas. MPOA alpha1-receptors exert similar wake-promoting actions. The current study examines the influence of alpha1-receptors located within MS on sleep-wake state. In addition, the extent to which alpha1- and beta-receptors located within MS and MPOA interact in the modulation of behavioral state was investigated by examining the effects of individual or combined infusion of alpha1- and beta-agonists into these regions. Results show that alpha1-receptors located within MS exert wake-promoting actions. Within both MS and MPOA, additive wake-promoting actions were observed with alpha1- and beta-receptor stimulation, the sum of which contributes to the overall arousal state of the animal.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0735-7044
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12708531-Adrenergic alpha-Agonists,
pubmed-meshheading:12708531-Adrenergic beta-Agonists,
pubmed-meshheading:12708531-Animals,
pubmed-meshheading:12708531-Circadian Rhythm,
pubmed-meshheading:12708531-Dose-Response Relationship, Drug,
pubmed-meshheading:12708531-Electroencephalography,
pubmed-meshheading:12708531-Electromyography,
pubmed-meshheading:12708531-Isoproterenol,
pubmed-meshheading:12708531-Male,
pubmed-meshheading:12708531-Medial Forebrain Bundle,
pubmed-meshheading:12708531-Phenylephrine,
pubmed-meshheading:12708531-Preoptic Area,
pubmed-meshheading:12708531-Rats,
pubmed-meshheading:12708531-Rats, Sprague-Dawley,
pubmed-meshheading:12708531-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:12708531-Receptors, Adrenergic, beta,
pubmed-meshheading:12708531-Septal Nuclei,
pubmed-meshheading:12708531-Sleep, REM,
pubmed-meshheading:12708531-Wakefulness
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pubmed:year |
2003
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pubmed:articleTitle |
Additive wake-promoting actions of medial basal forebrain noradrenergic alpha1- and beta-receptor stimulation.
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pubmed:affiliation |
Department of Psychology, University of Wisconsin-Madison, 53706, USA. berridge@wisc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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