Linked Life Data

12706856

Source:http://linkedlifedata.com/resource/pubmed/id/12706856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-22
pubmed:abstractText
Caffeine exerts potent chemopreventive action against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland carcinogenesis, but acts as a co-carcinogen in the colon. The present work was performed to clarify mechanisms underling these organ dependent actions. Female F344 rats were given PhIP and caffeine, PhIP alone, caffeine alone or no treatment for 4 weeks. PhIP-DNA adduct formation in the colon was significantly higher in the PhIP+caffeine than in the PhIP group, but levels in the mammary glands showed no inter-group differences. CYP1A2 mRNA expression in the livers of the PhIP+caffeine group tended to be higher than in either the PhIP or the caffeine alone groups. High mRNA expression for both N-acetyltransferase (NAT) 1 and NAT2 was observed in the colon, with less expression in the mammary gland. The levels of four DNA-repair enzymes were not influenced by the caffeine treatment. In conclusion, only increased level of DNA adducts in the colon partially related to the modifying effects of caffeine on PhIP-induced rat carcinogenesis. Thus, other unknown factors must be contributory.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
194
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12706856-Animals, pubmed-meshheading:12706856-Antimetabolites, Antineoplastic, pubmed-meshheading:12706856-Blotting, Western, pubmed-meshheading:12706856-Body Weight, pubmed-meshheading:12706856-Breast, pubmed-meshheading:12706856-Bromodeoxyuridine, pubmed-meshheading:12706856-Caffeine, pubmed-meshheading:12706856-Carcinogens, pubmed-meshheading:12706856-Central Nervous System Stimulants, pubmed-meshheading:12706856-Colon, pubmed-meshheading:12706856-Colonic Neoplasms, pubmed-meshheading:12706856-Cytochrome P-450 CYP1A2, pubmed-meshheading:12706856-DNA, Single-Stranded, pubmed-meshheading:12706856-DNA Adducts, pubmed-meshheading:12706856-DNA Repair, pubmed-meshheading:12706856-Female, pubmed-meshheading:12706856-Imidazoles, pubmed-meshheading:12706856-Immunohistochemistry, pubmed-meshheading:12706856-Liver, pubmed-meshheading:12706856-Mammary Neoplasms, Animal, pubmed-meshheading:12706856-Organ Size, pubmed-meshheading:12706856-RNA, Messenger, pubmed-meshheading:12706856-Rats, pubmed-meshheading:12706856-Rats, Inbred F344, pubmed-meshheading:12706856-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2003
pubmed:articleTitle
Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
pubmed:affiliation
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. taisho@med.nagoya-cu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't