Linked Life Data

12706753

Source:http://linkedlifedata.com/resource/pubmed/id/12706753

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-22
pubmed:abstractText
Rodents often demonstrate a profound depression in physiological function following acute exposure to toxic xenobiotic agents. This effect, termed the hypothermic response, is primarily characterized by significant decreases in core temperature and heart rate and is generally accompanied by similar deficits in other important functional parameters. This response appears to be remarkably consistent across a wide variety of toxic agents and exposure regimens; however, the magnitude and duration of the induced effects may be modulated by changes in dose, animal mass, and environmental conditions. While the initiating stimulus and underlying mechanism(s) remains elusive, this response may represent an inherent reflexive pattern that is unique to the rodent and serves to attenuate the induced toxicity. Given that rodents are the primary animal species used in toxicological studies, it is important to consider this hypothermic response and its modulatory factors when interpreting the results of such studies and extrapolating those results to man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-47
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Cardiac and thermoregulatory responses to inhaled pollutants in healthy and compromised rodents: modulation via interaction with environmental factors.
pubmed:affiliation
Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. watkinson.william@epa.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.