Linked Life Data

12706371

Source:http://linkedlifedata.com/resource/pubmed/id/12706371

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-4-22
pubmed:abstractText
The role of DHT in the development of BPH has resulted in the formulation of several drugs, which have been designed to inhibit the formation of DHT by the 5alpha-reductase enzymes (5alpha-reductase type I (5alpha-RI) & 5alpha-reductase type II (5alpha-RII)). Although the function of these enzymes is well understood, the biochemical stimulus for initiation of 5alpha-RI and II gene expression has not been described. Study of a co-culture model indicated the presence of a diffusible factor secreted by prostatic fibroblast cells, which is responsible for the transcription of 5alpha-II mRNA in primary prostatic epithelial cells. In this study, we describe the partial characterisation of a fibroblast-secreted, soluble factor which we believe induces the transcription of 5alpha-RII mRNA in long-term primary cultures of prostate epithelial cells which can no longer transcribe 5alpha-RII mRNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0959-8049
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1004-11
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Induction of 5alpha-reductase type II mRNA transcription in primary cultured prostate epithelial cells by a soluble factor produced by primary cultured prostate fibroblast cells.
pubmed:affiliation
Breast Cancer Research Group, Department of Oncology, University of Edinburgh, Paderewski Building, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK. cbay@srv0.med.ed.ac.uk
pubmed:publicationType
Journal Article