Linked Life Data

12703549

Source:http://linkedlifedata.com/resource/pubmed/id/12703549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-21
pubmed:abstractText
Germ cell apoptosis is very common during various stages of mammalian testicular development. However, our understanding of the mechanisms underlying male germ cell apoptosis is still limited. This review firstly covers the general features of germ cell death in normal testes of fetal, neonatal, and adult mice from electron microscopy (EM) and terminal dUTP nick-end labeling (TUNEL) staining. The issue of whether the Fas and Fas ligand (FasL) system and/or the Bax and Bcl-2 system is involved in the induction of germ cell apoptosis in normal and damaged testes will then be addressed, including a special consideration of the ischemia-reperfusion model, the endocrine disruptor-treated model, and others. Finally, this review will propose that the process of normal spermatogenesis seems skillfull in taking advantage of apoptotic processes of germ cells and that different molecular pathways may be triggered to induce male germ cell apoptosis, depending upon the physiological and pathological states of germ cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0914-9465
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Germ cell apoptosis and its molecular trigger in mouse testes.
pubmed:affiliation
Department of Histology and Cell Biology, Nagasaki University School of Medicine, Nagasaki, Japan. tkoji@net.nagasaki-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't