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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5622
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pubmed:dateCreated |
2003-5-16
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pubmed:abstractText |
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CHUK protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IRF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IRF7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/TBK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1148-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12702806-Cell Line,
pubmed-meshheading:12702806-DNA-Binding Proteins,
pubmed-meshheading:12702806-Enzyme Activation,
pubmed-meshheading:12702806-Gene Expression Regulation, Viral,
pubmed-meshheading:12702806-Hepacivirus,
pubmed-meshheading:12702806-Humans,
pubmed-meshheading:12702806-I-kappa B Kinase,
pubmed-meshheading:12702806-Interferon Regulatory Factor-3,
pubmed-meshheading:12702806-Interferon Regulatory Factor-7,
pubmed-meshheading:12702806-Interferon Type I,
pubmed-meshheading:12702806-Phosphorylation,
pubmed-meshheading:12702806-Promoter Regions, Genetic,
pubmed-meshheading:12702806-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12702806-RNA, Small Interfering,
pubmed-meshheading:12702806-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Triggering the interferon antiviral response through an IKK-related pathway.
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pubmed:affiliation |
Lady Davis Institute for Medical Research-Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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