12700925

Source:http://linkedlifedata.com/resource/pubmed/id/12700925

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017817, umls-concept:C0162638, umls-concept:C0178539, umls-concept:C0205082, umls-concept:C0332281, umls-concept:C0333668
pubmed:issue	6
pubmed:dateCreated	2003-6-12
pubmed:abstractText	The quaternary benzophenanthridine alkaloid sanguinarine exhibits a broad range of activity, including cytotoxicity against various human tumour and normal cell lines. Here, we examined its potency as an anticancer drug.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7806519
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic, http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Benzophenanthridines, http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CASP7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 7, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione, http://linkedlifedata.com/resource/pubmed/chemical/HOE 33342, http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents, http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines, http://linkedlifedata.com/resource/pubmed/chemical/Oxazines, http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species, http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes, http://linkedlifedata.com/resource/pubmed/chemical/resazurin, http://linkedlifedata.com/resource/pubmed/chemical/sanguinarine
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0344-5704
pubmed:author	pubmed-author:BarthomeufChantalC, pubmed-author:DebitonEricE, pubmed-author:LegaultJeanJ, pubmed-author:MadelmontJean-ClaudeJC
pubmed:issnType	Print
pubmed:volume	51
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	474-82
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12700925-Alkaloids, pubmed-meshheading:12700925-Antineoplastic Agents, Phytogenic, pubmed-meshheading:12700925-Apoptosis, pubmed-meshheading:12700925-Benzimidazoles, pubmed-meshheading:12700925-Benzophenanthridines, pubmed-meshheading:12700925-Caspase 3, pubmed-meshheading:12700925-Caspase 7, pubmed-meshheading:12700925-Caspases, pubmed-meshheading:12700925-Cell Division, pubmed-meshheading:12700925-Cell Survival, pubmed-meshheading:12700925-Cells, Cultured, pubmed-meshheading:12700925-DNA Fragmentation, pubmed-meshheading:12700925-Electrophoresis, Agar Gel, pubmed-meshheading:12700925-Glutathione, pubmed-meshheading:12700925-Humans, pubmed-meshheading:12700925-Indicators and Reagents, pubmed-meshheading:12700925-Isoquinolines, pubmed-meshheading:12700925-Neoplasms, pubmed-meshheading:12700925-Oxazines, pubmed-meshheading:12700925-Reactive Oxygen Species, pubmed-meshheading:12700925-Tumor Cells, Cultured, pubmed-meshheading:12700925-Xanthenes
pubmed:year	2003
pubmed:articleTitle	Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion.
pubmed:affiliation	UMR-INSERM U-484, Rue Montalembert, BP 184, 63005, Clermont-Ferrand, France.
pubmed:publicationType	Journal Article