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rdf:type |
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lifeskim:mentions |
umls-concept:C0015811,
umls-concept:C0043240,
umls-concept:C0175649,
umls-concept:C0205107,
umls-concept:C0205195,
umls-concept:C0262950,
umls-concept:C0374711,
umls-concept:C0440257,
umls-concept:C0527443,
umls-concept:C0560175,
umls-concept:C1280551,
umls-concept:C1457869,
umls-concept:C1705181,
umls-concept:C1706209
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pubmed:issue |
13
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pubmed:dateCreated |
2003-4-17
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pubmed:abstractText |
Total hip arthroplasty (THA) has become an almost standard procedure for the treatment of various hip lesions. However, one of the limitations has been the mechanical loosening of the prosthesis, a condition termed peri-prosthetic osteolysis. Consequently, at revision surgery, various grades of bone defect are often noted. Alternative approaches aimed at overcoming this problem have included a special design of the revision prosthesis and allo- or autogeneic bone grafting in combination with or without biomaterials. In a further attempt to address the loosening of the prosthesis, we have combined human bone morphogenetic protein-2, produced by DNA recombination (rhBMP-2) with a new synthetic biodegradable polymer (poly-D,L-lactic-acid-para-dioxanone-polyethyleneglycol block co-polymer; PLA-DX-PEG). We present data on the efficacy of the rhBMP-2 laden prosthesis to reconstruct a bone defect in a canine model. In this model, medial half of the proximal femur was surgically resected to create a bone defect that was repaired with the rhBMP-2/PLA-DX-PEG composite. Twelve weeks after implantation, the original bone defects in the rhBMP-2 treatment groups had been repaired. Thus, this type of 'hybrid' prosthesis may provide a new modality to repair bone defects or restore lost bone mass encountered in revision arthroplasty.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0142-9612
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2153-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12699651-Absorbable Implants,
pubmed-meshheading:12699651-Animals,
pubmed-meshheading:12699651-Arthroplasty, Replacement, Hip,
pubmed-meshheading:12699651-Bone Morphogenetic Protein 2,
pubmed-meshheading:12699651-Bone Morphogenetic Proteins,
pubmed-meshheading:12699651-Coated Materials, Biocompatible,
pubmed-meshheading:12699651-Combined Modality Therapy,
pubmed-meshheading:12699651-Dogs,
pubmed-meshheading:12699651-Equipment Failure Analysis,
pubmed-meshheading:12699651-Femoral Fractures,
pubmed-meshheading:12699651-Hip Prosthesis,
pubmed-meshheading:12699651-Joint Instability,
pubmed-meshheading:12699651-Lactates,
pubmed-meshheading:12699651-Male,
pubmed-meshheading:12699651-Polyethylene Glycols,
pubmed-meshheading:12699651-Porosity,
pubmed-meshheading:12699651-Prosthesis Design,
pubmed-meshheading:12699651-Reoperation,
pubmed-meshheading:12699651-Surface Properties,
pubmed-meshheading:12699651-Transforming Growth Factor beta
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pubmed:year |
2003
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pubmed:articleTitle |
Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies,
Validation Studies
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