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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-8-25
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pubmed:abstractText |
Reduced tolerance of steatotic livers to ischemic injury is considered to correlate with impaired microcirculation. The aim of this study was to investigate the impact of heat-shock preconditioning (HSPC) on microcirculatory failure after ischemia/reperfusion (I/R) in steatotic livers by means of intra-vital fluorescence microscopy. Obese Zucker rats were used. In the HS group, rats underwent whole-body hyperthermia followed by 60-min partial liver ischemia. In group IR, rats were exposed only to ischemia. Microcirculation parameters (sinusoidal perfusion rate, sinusoidal diameter, leukocyte-endothelial interaction) were significantly better preserved in the HS group than in the IR group. Liver enzymes, oxygenated glutathione/reduced glutathione (GSSG/GSH) ratio, and electron microscopy showed less damage in the HS group. A marked expression of heat shock protein 72 (HSP72) and heme oxygenase (HO-1) was found only in the livers of group HS. HSPC mitigated the I/R injury of steatotic livers by preventing post-ischemic failure of microcirculation. This beneficial effect was found to be associated with the induction of HSP72 and HO-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0934-0874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
456-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12698240-Alanine Transaminase,
pubmed-meshheading:12698240-Animals,
pubmed-meshheading:12698240-Blood Pressure,
pubmed-meshheading:12698240-Fatty Liver,
pubmed-meshheading:12698240-Glutamyl Aminopeptidase,
pubmed-meshheading:12698240-HSP72 Heat-Shock Proteins,
pubmed-meshheading:12698240-Heat-Shock Proteins,
pubmed-meshheading:12698240-Heat-Shock Response,
pubmed-meshheading:12698240-Heme Oxygenase (Decyclizing),
pubmed-meshheading:12698240-Heme Oxygenase-1,
pubmed-meshheading:12698240-L-Lactate Dehydrogenase,
pubmed-meshheading:12698240-Liver,
pubmed-meshheading:12698240-Liver Circulation,
pubmed-meshheading:12698240-Liver Transplantation,
pubmed-meshheading:12698240-Male,
pubmed-meshheading:12698240-Microcirculation,
pubmed-meshheading:12698240-Microscopy, Electron,
pubmed-meshheading:12698240-Rats,
pubmed-meshheading:12698240-Rats, Zucker,
pubmed-meshheading:12698240-Reperfusion Injury,
pubmed-meshheading:12698240-Transplantation Conditioning
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pubmed:year |
2003
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pubmed:articleTitle |
Heat-shock preconditioning protects fatty livers in genetically obese Zucker rats from microvascular perfusion failure after ischemia reperfusion.
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pubmed:affiliation |
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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