Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-4-16
pubmed:abstractText
Phospholipase D (PLD) has been implicated in the signal transduction pathways initiated by several mitogenic protein tyrosine kinases. We demonstrate for the first time that most notably PLD2 and to a lesser extent the PLD1 isoform are tyrosine phosphorylated by c-Src tyrosine kinase via direct association. Moreover, epidermal growth factor induced tyrosine phosphorylation of PLD2 and its interaction with c-Src in A431 cells. Interaction between these proteins is via the pleckstrin homology domain of PLD2 and the catalytic domain of c-Src. Coexpression of PLD1 or PLD2 with c-Src synergistically enhances cellular proliferation compared with expression of either molecule. While PLD activity as a lipid-hydrolyzing enzyme is not affected by c-Src, wild-type PLDs but not catalytically inactive PLD mutants significantly increase c-Src kinase activity, up-regulating c-Src-mediated paxillin phosphorylation and extracellular signal-regulated kinase activity. These results demonstrate the critical role of PLD catalytic activity in the stimulation of Src signaling. In conclusion, we provide the first evidence that c-Src acts as a kinase of PLD and PLD acts as an activator of c-Src. This transmodulation between c-Src and PLD may contribute to the promotion of cellular proliferation via amplification of mitogenic signaling pathways.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10049738, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10216475, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10358935, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10360179, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10425391, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10523655, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10611224, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10788479, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-10954702, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11007482, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11090971, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11114743, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11114744, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11134345, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11185526, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11278912, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11459228, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11522330, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11530878, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11577003, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11723127, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11736640, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11741292, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11741937, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-11821392, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-1702788, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-1999479, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-2446642, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-2482802, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-2599112, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-3103925, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-7477381, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-7540725, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-7685656, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-7688944, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-7890731, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-8022819, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-8196611, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-8672527, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-8681422, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-8702633, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9013646, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9201251, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9252384, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9376219, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9395408, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-942051, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9421199, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9442882, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9792719, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9837959, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9867870, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9873061, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9882614, http://linkedlifedata.com/resource/pubmed/commentcorrection/12697812-9891083
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CSK tyrosine-protein kinase, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/PXN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Paxillin, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase D, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Pxn protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Pxn protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine, http://linkedlifedata.com/resource/pubmed/chemical/phospholipase D1, http://linkedlifedata.com/resource/pubmed/chemical/phospholipase D2
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3103-15
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
More...