Linked Life Data

12697724

Source:http://linkedlifedata.com/resource/pubmed/id/12697724

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12697724rdf:typepubmed:Citationlld:pubmed
pubmed-article:12697724lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C1366557lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C1704256lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C1517714lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C0032008lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C0006668lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C0441472lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C1314939lld:lifeskim
pubmed-article:12697724lifeskim:mentionsumls-concept:C0332120lld:lifeskim
pubmed-article:12697724pubmed:issue5lld:pubmed
pubmed-article:12697724pubmed:dateCreated2003-4-16lld:pubmed
pubmed-article:12697724pubmed:abstractTextCalcitonin-like pituitary peptide, which is synthesized and secreted by gonadotrophs of the rat anterior pituitary (AP) gland, is a potent inhibitor of prolactin biosynthesis and lactotroph cell proliferation. Because TGF-beta 1 is an autocrine inhibitor of lactotroph cell proliferation, we investigated a possibility that calcitonin (CT) interacts with TGF-beta 1 to inhibit lactotroph cell proliferation. The actions of CT on GGH3 cell proliferation were examined in the absence or presence of anti-TGF-beta 1 serum. Subsequent experiments tested the effects of CT on TGF-beta 1 mRNA abundance as well as TGF-beta 1 synthesis. The studies also tested whether the stimulatory action of CT on TGF-beta 1 mRNA expression involves stabilization of TGF-beta 1 mRNA. Finally, the experiments investigated in vivo actions of CT on TGF-beta 1 synthesis in the AP gland. This was accomplished by studying the changes induced by i.v. administered CT in TGF-beta 1-immunopositive cell populations of adult female rat AP glands. The results have shown that the inhibitory action of CT on proliferation of GGH3 cells was attenuated by rabbit anti-TGF-beta 1 serum. Moreover, CT stimulated TGF-beta 1 mRNA expression, as well as TGF-beta 1 synthesis, in a dose-dependent fashion. Stimulatory action of CT on TGF-beta 1 expression may be posttranscriptional, because it significantly increased TGF-beta 1 mRNA stability. When administered in vivo, CT significantly increased TGF-beta 1-immunopositive cell populations of adult female rat AP gland. Colocalization studies for prolactin and TGF-beta 1 suggest that CT increased TGF-beta 1 synthesis in lactotrophs, and possibly in nonlactotroph cell populations. These results suggest that antiproliferative action of CT on lactotrophs may, at least in part, be mediated by CT-induced TGF-beta 1 expression.lld:pubmed
pubmed-article:12697724pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:languageenglld:pubmed
pubmed-article:12697724pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:citationSubsetAIMlld:pubmed
pubmed-article:12697724pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12697724pubmed:statusMEDLINElld:pubmed
pubmed-article:12697724pubmed:monthMaylld:pubmed
pubmed-article:12697724pubmed:issn0013-7227lld:pubmed
pubmed-article:12697724pubmed:authorpubmed-author:RenYuanYlld:pubmed
pubmed-article:12697724pubmed:authorpubmed-author:SunYa-PingYPlld:pubmed
pubmed-article:12697724pubmed:authorpubmed-author:ShahGirish...lld:pubmed
pubmed-article:12697724pubmed:authorpubmed-author:WangYong...lld:pubmed
pubmed-article:12697724pubmed:authorpubmed-author:LeeTae-JinTJlld:pubmed
pubmed-article:12697724pubmed:issnTypePrintlld:pubmed
pubmed-article:12697724pubmed:volume144lld:pubmed
pubmed-article:12697724pubmed:ownerNLMlld:pubmed
pubmed-article:12697724pubmed:authorsCompleteYlld:pubmed
pubmed-article:12697724pubmed:pagination2164-71lld:pubmed
pubmed-article:12697724pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:meshHeadingpubmed-meshheading:12697724...lld:pubmed
pubmed-article:12697724pubmed:year2003lld:pubmed
pubmed-article:12697724pubmed:articleTitleAntiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland: evidence for the involvement of transforming growth factor beta 1 in calcitonin action.lld:pubmed
pubmed-article:12697724pubmed:affiliationDepartment of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.lld:pubmed
pubmed-article:12697724pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12697724pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
entrez-gene:24241entrezgene:pubmedpubmed-article:12697724lld:entrezgene
entrez-gene:59086entrezgene:pubmedpubmed-article:12697724lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12697724lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12697724lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12697724lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12697724lld:pubmed