Source:http://linkedlifedata.com/resource/pubmed/id/12697040
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-4-16
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| pubmed:abstractText |
The effects of neonatal passive immunization against GHRH on bone was examined in male and female rats. Pups were treated subcutaneously with GHRH-antiserum (GHRH-Ab) from day 1 to day 10 of age. Bone mineral content (BMC) and bone mineral density (BMD) were evaluated at monthly intervals until 7 months. Markers of bone resorption (urinary lysylpyridinoline, LP), bone formation (serum osteocalcin, OC) and serum IGF-I were measured at 2, 3 and 7 months. In male rats, GHRH-Ab did not modify BMC and BMD when compared with controls. In contrast, female rats demonstrated lower whole body and femoral BMC and BMD from 2 to 7 months of age. Reduced bone growth in the females was associated with lower IGF-I levels than controls at 2 and 3 months of age, whereas in males IGF-I titers did not change during the period of the study. LP excretion was higher in GHRH-Ab-treated rats at 2 and 3 months in both sexes. In females, no difference in OC values was recorded, whereas in GHRH-Ab-treated males, there was an increase in OC levels at 2 and 3 months. These data indicate that transient GHRH deprivation induces an osteopenic effect in female rats which is not evident in male rats.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Minerals,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/deoxypyridinoline
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0022-0795
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
177
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
93-100
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12697040-Amino Acids,
pubmed-meshheading:12697040-Animals,
pubmed-meshheading:12697040-Animals, Newborn,
pubmed-meshheading:12697040-Biological Markers,
pubmed-meshheading:12697040-Body Weight,
pubmed-meshheading:12697040-Bone Density,
pubmed-meshheading:12697040-Bone Remodeling,
pubmed-meshheading:12697040-Bone and Bones,
pubmed-meshheading:12697040-Female,
pubmed-meshheading:12697040-Growth Hormone-Releasing Hormone,
pubmed-meshheading:12697040-Immune Sera,
pubmed-meshheading:12697040-Immunization, Passive,
pubmed-meshheading:12697040-Insulin-Like Growth Factor I,
pubmed-meshheading:12697040-Male,
pubmed-meshheading:12697040-Minerals,
pubmed-meshheading:12697040-Osteocalcin,
pubmed-meshheading:12697040-Rats,
pubmed-meshheading:12697040-Rats, Sprague-Dawley,
pubmed-meshheading:12697040-Sex,
pubmed-meshheading:12697040-Sexual Maturation
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| pubmed:year |
2003
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| pubmed:articleTitle |
Long-term effects on bone of postnatal immunization against GHRH in female and male rats.
|
| pubmed:affiliation |
Department of Pharmacology, Chemotherapy and Medical Toxicology, Centre of Excellence of Neurodegenerative Diseases, University of Milan, Via Vanvitelli 32, Italy. Valeria.Sibilia@unimi.it
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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