Linked Life Data

12696934

Source:http://linkedlifedata.com/resource/pubmed/id/12696934

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-4-16
pubmed:abstractText
Sixty-two plant species from central China were purported to have insecticidal activity. Adult house fly (Musca domestica) toxicity assays were used to identify the two most active plants and guide the chromatographic isolation of the insecticidal components. The active ingredient of Senecio palmatusPall. (Asteraceae) was characterized as methyl (1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate (jacaranone) (1), previously known to have insect antifeedant activity. Mono- and bisglutathione (GSH) adducts are formed on incubation of 1 with GSH and rat liver GSH S-transferase. The toxic action of 1 in mice (intraperitoneal LD(50) = 150-200 mg/kg) is associated with both neurological signs and GSH depletion in liver 90 min after treatment. Paeonia suffruticosa var. papaveracea (Andr.) Kerner (Paeoniaceae) was the other active plant found here to have 2'-hydroxy-4'-methoxyacetophenone (paeonol) (2) as an insecticidal ingredient in the root and in one case, for the whole plant, contaminated with S-tert-butylthiomethyl O,O-diethyl phosphorodithioate (terbufos) (3), a synthetic anticholinesterase insecticide.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-8561
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2544-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Insecticides in Chinese medicinal plants: survey leading to jacaranone, a neurotoxicant and glutathione-reactive quinol.
pubmed:affiliation
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't