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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-4-16
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pubmed:abstractText |
Skin sensitization potential of low molecular weight chemicals was assessed by analyzing peptide-conjugate formation. Chemicals were incubated with a peptide, glutathione, and resultant mixtures were analyzed by mass spectrometry. Eighteen chemicals were assessed, and new peaks corresponding to chemical-peptide conjugates were detected for 13 of 14 known sensitizers. Conjugates were not detected for 4 negative chemicals. The method has advantages as a simple screening assay for assessing the sensitization potential of chemicals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0388-1350
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12696181-Animals,
pubmed-meshheading:12696181-Dermatitis, Allergic Contact,
pubmed-meshheading:12696181-Dinitrochlorobenzene,
pubmed-meshheading:12696181-Glutathione,
pubmed-meshheading:12696181-Guinea Pigs,
pubmed-meshheading:12696181-Mass Spectrometry,
pubmed-meshheading:12696181-Peptides,
pubmed-meshheading:12696181-Protein Binding,
pubmed-meshheading:12696181-Skin Irritancy Tests,
pubmed-meshheading:12696181-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:12696181-Toxins, Biological,
pubmed-meshheading:12696181-Trinitrobenzenesulfonic Acid
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pubmed:year |
2003
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pubmed:articleTitle |
Peptide-binding assessment using mass spectrometry as a new screening method for skin sensitization.
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pubmed:affiliation |
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-8558, Japan.
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pubmed:publicationType |
Journal Article
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