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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2003-4-22
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pubmed:abstractText |
Alveolar hypoxia acutely elicits pulmonary vasoconstriction (HPV). Chronic hypoxia (CH), despite attenuating HPV, causes pulmonary hypertension (CH-PHT). HPV results, in part, from inhibition of O2-sensitive, voltage-gated potassium channels (Kv) in pulmonary artery smooth muscle cells (PASMCs). CH decreases Kv channel current/expression and depolarizes and causes Ca2+ overload in PASMCs. We hypothesize that Kv gene transfer would normalize the pulmonary circulation (restore HPV and reduce CH-PHT), despite ongoing hypoxia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:ArcherStephen LSL,
pubmed-author:DyckJason R BJR,
pubmed-author:HarryGwynethG,
pubmed-author:HashimotoKyokoK,
pubmed-author:KoshalArvindA,
pubmed-author:McMurtryM SeanMS,
pubmed-author:MichelakisEvangelos DED,
pubmed-author:MoudgilRohitR,
pubmed-author:PozegZlatko IZI,
pubmed-author:SultanianRichardR,
pubmed-author:ThébaudBernardB,
pubmed-author:WangShaohuaS,
pubmed-author:WuXi-ChenXC
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2037-44
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12695303-Adenoviridae,
pubmed-meshheading:12695303-Administration, Inhalation,
pubmed-meshheading:12695303-Animals,
pubmed-meshheading:12695303-Anoxia,
pubmed-meshheading:12695303-Cardiac Output,
pubmed-meshheading:12695303-Chronic Disease,
pubmed-meshheading:12695303-Gene Therapy,
pubmed-meshheading:12695303-Gene Transfer Techniques,
pubmed-meshheading:12695303-Genes, Reporter,
pubmed-meshheading:12695303-Genetic Vectors,
pubmed-meshheading:12695303-Hemodynamics,
pubmed-meshheading:12695303-Hypertension, Pulmonary,
pubmed-meshheading:12695303-Kv1.5 Potassium Channel,
pubmed-meshheading:12695303-Male,
pubmed-meshheading:12695303-Muscle, Smooth, Vascular,
pubmed-meshheading:12695303-Patch-Clamp Techniques,
pubmed-meshheading:12695303-Potassium Channels,
pubmed-meshheading:12695303-Potassium Channels, Voltage-Gated,
pubmed-meshheading:12695303-Pulmonary Artery,
pubmed-meshheading:12695303-Rats,
pubmed-meshheading:12695303-Rats, Sprague-Dawley,
pubmed-meshheading:12695303-Vascular Resistance,
pubmed-meshheading:12695303-Vasoconstriction
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pubmed:year |
2003
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pubmed:articleTitle |
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats.
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pubmed:affiliation |
Vascular Biology Group, Cardiology, University of Alberta, Edmonton, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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