Linked Life Data

12694532

Source:http://linkedlifedata.com/resource/pubmed/id/12694532

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-4-15
pubmed:abstractText
Both caffeine and the inactivation of RCC1, the guanine-nucleotide exchange factor (GEF) of Ran, induce premature chromatin condensation (PCC) in hamster BHK21 cells arrested in the S-phase, suggesting that RCC1 is a target for caffeine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ATR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Adenine, http://linkedlifedata.com/resource/pubmed/chemical/Caffeine, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants, http://linkedlifedata.com/resource/pubmed/chemical/Chromatin, http://linkedlifedata.com/resource/pubmed/chemical/Deoxyadenosines, http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors, http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotides, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/RCC1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/histone H1 kinase, http://linkedlifedata.com/resource/pubmed/chemical/ran GTP-Binding Protein
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1356-9597
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
423-35
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12694532-Adenine, pubmed-meshheading:12694532-Animals, pubmed-meshheading:12694532-Caffeine, pubmed-meshheading:12694532-Cell Cycle Proteins, pubmed-meshheading:12694532-Cell Line, pubmed-meshheading:12694532-Central Nervous System Stimulants, pubmed-meshheading:12694532-Chromatin, pubmed-meshheading:12694532-Cricetinae, pubmed-meshheading:12694532-Deoxyadenosines, pubmed-meshheading:12694532-Guanine Nucleotide Exchange Factors, pubmed-meshheading:12694532-Guanine Nucleotides, pubmed-meshheading:12694532-Humans, pubmed-meshheading:12694532-Molecular Mimicry, pubmed-meshheading:12694532-Nuclear Proteins, pubmed-meshheading:12694532-Protein Kinases, pubmed-meshheading:12694532-Protein-Serine-Threonine Kinases, pubmed-meshheading:12694532-Recombinant Proteins, pubmed-meshheading:12694532-S Phase, pubmed-meshheading:12694532-Signal Transduction, pubmed-meshheading:12694532-Temperature, pubmed-meshheading:12694532-ran GTP-Binding Protein
pubmed:year
2003
pubmed:articleTitle
Caffeine mimics adenine and 2'-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.
pubmed:affiliation
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't