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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-15
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pubmed:abstractText |
Cytokines are key factors that mediate the inflammatory process during periodontal disease. Recent works have shown that the levels of cytokine expression are regulated by genetic polymorphisms, and that these variations can interfere with the progression of disease. The-590 (C-->T) polymorphism of the IL4 gene is associated with high levels of IgE in asthmatic families, and the frequency of the T allele was increased in asthmatic children. The concentration of IgE in gingival tissue was found to be elevated in patients with periodontitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0303-6979
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12694433-Adult,
pubmed-meshheading:12694433-African Continental Ancestry Group,
pubmed-meshheading:12694433-Alleles,
pubmed-meshheading:12694433-Brazil,
pubmed-meshheading:12694433-Chi-Square Distribution,
pubmed-meshheading:12694433-Chronic Disease,
pubmed-meshheading:12694433-Cytosine,
pubmed-meshheading:12694433-Ethnic Groups,
pubmed-meshheading:12694433-European Continental Ancestry Group,
pubmed-meshheading:12694433-Gene Expression Regulation,
pubmed-meshheading:12694433-Gene Frequency,
pubmed-meshheading:12694433-Genetic Predisposition to Disease,
pubmed-meshheading:12694433-Genetic Variation,
pubmed-meshheading:12694433-Genotype,
pubmed-meshheading:12694433-Humans,
pubmed-meshheading:12694433-Interleukin-4,
pubmed-meshheading:12694433-Periodontitis,
pubmed-meshheading:12694433-Polymorphism, Genetic,
pubmed-meshheading:12694433-Promoter Regions, Genetic,
pubmed-meshheading:12694433-Thymine
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pubmed:year |
2003
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pubmed:articleTitle |
Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population.
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pubmed:affiliation |
Department of Morphology, Dental School of Piracicaba, State University of Campinas, Av. Limeira 901, CEP 13414-018, Piracicaba-SP, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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