Adiponectin (ADPN), the gene product of apM1, is the most abundant secretory protein of the adipose tissue in human plasma. Altered regulation (reduced synthesis) of this substance may be relevant to endothelial dysfunction and cardiovascular complications in patients with ESRD.
Laboratorio di Epidemiologia, Clinica e Fisiopatologia delle Malattie, Renali, e dell'Ipertensione Arteriosa, Istituto di Biomedicina, Reggio Calabria, Italy. carmine.zoccali@tin.it