Linked Life Data

12694301

Source:http://linkedlifedata.com/resource/pubmed/id/12694301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
84
pubmed:dateCreated
2003-4-15
pubmed:abstractText
Life demands intra- and intercellular communication in and between cells to respond and adapt to changes in the environment. Among signaling molecules, reactive oxygen (ROS) and nitrogen (RNS) species gained attention in facilitating intracellular communication and causing cell demise during pathology. Complexity was added with the notion that ROS and RNS signals overlap and/or produce synergistic, as well as antagonistic, effects. This is exemplified by using oxidized lipoproteins (oxLDL), or NO donors, in provoking the stabilization of two well recognized transcription factors, such as tumor suppressor p53 and hypoxia-inducible factor-1 alpha (HIF-1 alpha). Radical (i.e., superoxide) (O2-) formation in response to oxLDL is associated with p53, as well as HIF-1 alpha accumulation in human macrophages, a process that is antagonized by NO. On the other side, NO-elicited HIF-1 alpha stabilization is modulated by O2-. Thus, ROS- and RNS-signaling is important in understanding cell physiology and pathology, with the notion that marginal changes in the flux rates of either NO or O2- may shift vital signals used for communication into areas of pathology in close association with human diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0098-6577
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S22-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Nitric oxide, oxidative stress, and apoptosis.
pubmed:affiliation
University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Kaiserslautern, Germany.
pubmed:publicationType
Journal Article, Review