Source:http://linkedlifedata.com/resource/pubmed/id/12694231
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2003-4-15
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pubmed:abstractText |
Folate supplementation appears to reduce the risk for neural tube defects (NTDs). Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate metabolism pathway that has been extensively studied in different human populations. We examined the risk associated with having the thermolabile variant (TT) of MTHFR in a study of 175 American Caucasians with NTDs and their families. We found a significant association in patients compared with 195 unrelated controls [odds ratio (OR) = 2.13, 95% confidence interval (95% CI) = 1.11-4.09)], but not in mothers (OR = 1.29, 95% CI = 0.622-2.67) or in fathers (OR = 1.45, 95% CI = 0.681-3.09). We found no evidence for unequal transmission from parents to an affected child (p > 0.10). We failed to find a previously reported association for a combined haplotype for MTHFR and cystathionine beta-synthase, except in subjects with NTDs compared with 559 pooled controls (OR = 2.87, 95% CI = 1.03-8.03). We found no evidence for an association for a novel CA-repeat polymorphism identified in a gene closely linked to MTHFR (p > 0.10). Our studies continue to suggest that additional candidate genes other than MTHFR may be responsible for an increased risk to NTD in some American Caucasian families.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9163
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pubmed:author | |
pubmed:copyrightInfo |
Copyright Blackwell Munksgaard, 2003
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
210-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12694231-Cystathionine beta-Synthase,
pubmed-meshheading:12694231-Female,
pubmed-meshheading:12694231-Gene Frequency,
pubmed-meshheading:12694231-Haplotypes,
pubmed-meshheading:12694231-Humans,
pubmed-meshheading:12694231-Male,
pubmed-meshheading:12694231-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:12694231-Mutation,
pubmed-meshheading:12694231-Neural Tube Defects,
pubmed-meshheading:12694231-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:12694231-United States
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pubmed:year |
2003
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pubmed:articleTitle |
Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects.
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pubmed:affiliation |
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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