Source:http://linkedlifedata.com/resource/pubmed/id/12694213
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2003-4-15
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pubmed:abstractText |
Susceptibility to contact allergy may be influenced by genetically determined alterations in the production of pro- and anti-inflammatory cytokines. This report focuses on functional polymorphisms in the genes encoding for several cytokines involved in the pathogenesis of contact allergic responses, including tumour necrosis factor (TNF)-alpha (G-238 A, G-308 A), interleukin (IL)-1beta (C-511G, T+ 3953C), its natural antagonist, the IL-1 receptor antagonist (VNTR intron 2), and IL-6 (G-174C). Polymorphisms were investigated by PCR techniques among polysensitized individuals, defined as individuals with confirmed contact sensitization to para-substituted aryl compounds and at least one other structurally unrelated allergen (n = 86), and healthy control individuals without a history of eczema (n = 310). The distribution of TNFA-308 genotypes was significantly different in these groups (Padjusted= 0.0378). Compared with carriers of 2 wild-type alleles (TNFA-308*1/1 (*G/G)), carriers of the TNFA-308*1/2 (*G/A) and TNFA-308*2/2 (*A/A) genotypes tended to be more common among polysensitized individuals [OR = 1.54, 95% CI (0.92-2.55) and OR = 2.36 (0.84-6.51), respectively]. No significantly different distribution of genotypes was detected at any other polymorphic loci among control individuals without eczema and polysensitized subjects. These findings suggest a possible relationship between the TNFA-308 polymorphism and contact allergy. The results need to be confirmed in future studies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0105-1873
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12694213-Adult,
pubmed-meshheading:12694213-Age Distribution,
pubmed-meshheading:12694213-Alleles,
pubmed-meshheading:12694213-Austria,
pubmed-meshheading:12694213-Case-Control Studies,
pubmed-meshheading:12694213-Cytokines,
pubmed-meshheading:12694213-Dermatitis, Allergic Contact,
pubmed-meshheading:12694213-Dermatitis, Atopic,
pubmed-meshheading:12694213-Female,
pubmed-meshheading:12694213-Gene Frequency,
pubmed-meshheading:12694213-Genetic Predisposition to Disease,
pubmed-meshheading:12694213-Genotype,
pubmed-meshheading:12694213-Humans,
pubmed-meshheading:12694213-Incidence,
pubmed-meshheading:12694213-Interleukin-1,
pubmed-meshheading:12694213-Male,
pubmed-meshheading:12694213-Middle Aged,
pubmed-meshheading:12694213-Polymorphism, Genetic,
pubmed-meshheading:12694213-Probability,
pubmed-meshheading:12694213-Receptors, Interleukin-1,
pubmed-meshheading:12694213-Reference Values,
pubmed-meshheading:12694213-Sex Distribution,
pubmed-meshheading:12694213-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Cytokine gene polymorphisms in allergic contact dermatitis.
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pubmed:affiliation |
Department of Occupational Health, Georg-August-University, Göttingen, Germany. gwestph@gwdg.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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