Source:http://linkedlifedata.com/resource/pubmed/id/12692888
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2003-4-14
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| pubmed:abstractText |
A simple and efficient strategy to convert the racemic mixture of 8-chloro-2-(2,6-difluorophenylmethyl)-2,3-dihydro-3-methyl-1,2,5-benzothiadiazepin-4(5H)-one 1,1-dioxide, a new anti-HIV-1 agent targeted to reverse transcriptase, into the more active (S)-enantiomer is described. The method utilizes repetition of the following two steps: 1) semipreparative enantioseparation by HPLC on chiral stationary phase; 2) base-induced racemization of the less active (R)-enantiomer.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0899-0042
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
429-32
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| pubmed:dateRevised |
2003-11-4
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| pubmed:year |
2003
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| pubmed:articleTitle |
Conversion of a racemic mixture of 8-chloro-2-(2,6-difluorophenylmethyl)-2,3-dihydro-3-methyl-1,2,5-benzothiadiazepin-4(5h)-one 1,1-dioxide into a single enantiomer via a chromatographic resolution/racemization method.
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| pubmed:affiliation |
Istituto Superiore di Sanità, Laboratorio di Chimica del Farmaco, Rome, Italy.
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| pubmed:publicationType |
Journal Article
|