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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-4-14
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pubmed:abstractText |
In this report, we examined plasma stromal cell-derived factor-1 levels in normal healthy donors for allogeneic peripheral blood stem cell transplantation (PBSCT) and in patients for autologous PBSCT using an enzyme-linked immunosorbent assay. The average level of plasma stromal cell-derived factor-1 was 2197 pg/ml before granulocyte colony-stimulating factor administration and 1899 pg/ml on day 4, demonstrating a significant decrease in the peripheral blood of healthy donors (P=0.0003). In patients for autologous PBSCT, a significant decrease of plasma stromal cell-derived factor-1 in the peripheral blood was also observed (P=0.0464). However, the physiologic gradient of stromal cell-derived factor-1 between peripheral blood and bone marrow was never inverted in normal healthy donors or in autologous PBSCT patients. Our results suggest that stromal cell-derived factor-1 may not be involved in the granulocyte colony-stimulating factor-induced release of CD34(+) cells to the peripheral blood. Further studies of a possible additive effect of granulocyte colony-stimulating factor and stromal cell-derived factor-1 are warranted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Filgrastim,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0268-3369
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pubmed:author |
pubmed-author:FujiiKK,
pubmed-author:FujiiNN,
pubmed-author:HaradaMM,
pubmed-author:HongoSS,
pubmed-author:IkedaKK,
pubmed-author:ImaiTT,
pubmed-author:IshikuraHH,
pubmed-author:IshimaruFF,
pubmed-author:KanedaKK,
pubmed-author:KozukaTT,
pubmed-author:MasudaKK,
pubmed-author:NiiyaKK,
pubmed-author:ShinagawaKK,
pubmed-author:TanimotoMM,
pubmed-author:WatanabeTT
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12692604-Adult,
pubmed-meshheading:12692604-Aged,
pubmed-meshheading:12692604-Antigens, CD,
pubmed-meshheading:12692604-Antigens, CD34,
pubmed-meshheading:12692604-Chemokine CXCL12,
pubmed-meshheading:12692604-Chemokines, CXC,
pubmed-meshheading:12692604-Female,
pubmed-meshheading:12692604-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:12692604-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:12692604-Hematopoietic Stem Cells,
pubmed-meshheading:12692604-Humans,
pubmed-meshheading:12692604-Male,
pubmed-meshheading:12692604-Middle Aged,
pubmed-meshheading:12692604-Recombinant Proteins,
pubmed-meshheading:12692604-Reference Values,
pubmed-meshheading:12692604-Stromal Cells,
pubmed-meshheading:12692604-Transplantation, Autologous,
pubmed-meshheading:12692604-Transplantation, Homologous
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pubmed:year |
2003
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pubmed:articleTitle |
Plasma stromal cell-derived factor-1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization.
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pubmed:affiliation |
Second Deparment of Internal Medicine, Okayama University Medical School, Okayama, Japan.
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pubmed:publicationType |
Journal Article
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