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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-1
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pubmed:abstractText |
The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins. A genome-wide scan of M. leprae detected 31 putative lipoproteins. Synthetic lipopeptides representing the 19-kD and 33-kD lipoproteins activated both monocytes and dendritic cells. Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression. TLR2 and TLR1 were more strongly expressed in lesions from the localized tuberculoid form (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease. These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:AkiraShizuoS,
pubmed-author:BrennanPatrick JPJ,
pubmed-author:ColeStewart TST,
pubmed-author:GodowskiPaul JPJ,
pubmed-author:KrutzikStephan RSR,
pubmed-author:LegaspiAnnalizaA,
pubmed-author:LiuPhilip TPT,
pubmed-author:MaedaYumiY,
pubmed-author:ModlinRobert LRL,
pubmed-author:NgYolanda WYW,
pubmed-author:NorgardMichael VMV,
pubmed-author:OchoaMaria TeresaMT,
pubmed-author:ReaThomas HTH,
pubmed-author:SarnoEuzenir NEN,
pubmed-author:SielingPeter APA,
pubmed-author:UematsuSatoshiS
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
525-32
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12692544-Animals,
pubmed-meshheading:12692544-Cytokines,
pubmed-meshheading:12692544-Humans,
pubmed-meshheading:12692544-Immunity, Innate,
pubmed-meshheading:12692544-Leprosy,
pubmed-meshheading:12692544-Lipoproteins,
pubmed-meshheading:12692544-Membrane Glycoproteins,
pubmed-meshheading:12692544-Mice,
pubmed-meshheading:12692544-Receptors, Cell Surface,
pubmed-meshheading:12692544-Toll-Like Receptor 1,
pubmed-meshheading:12692544-Toll-Like Receptor 2,
pubmed-meshheading:12692544-Toll-Like Receptors
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pubmed:year |
2003
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pubmed:articleTitle |
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
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pubmed:affiliation |
Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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