Source:http://linkedlifedata.com/resource/pubmed/id/12692290
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
Pt 5
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pubmed:dateCreated |
2003-4-14
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pubmed:databankReference | |
pubmed:abstractText |
The full-length genomic sequences were determined of Japanese swine and human hepatitis E virus (HEV) isolates (swJ13-1 and HE-JA1, respectively) with 100 % identity in the partial sequence of open reading frame (ORF) 2 (ORF2, 412 nt). swJ13-1 was isolated from a 4-month-old farm pig born in Hokkaido, Japan, in 2002 and HE-JA1 was recovered from a 55-year-old patient who lived in Hokkaido and who had contracted sporadic acute hepatitis E in 1997. Both isolates consisted of 7240 nt, excluding the poly(A) tail, and contained three ORFs (ORFs 1-3) that encoded proteins of 1707, 674 and 114 aa. The overall nucleotide sequence identity between them was 99.0 % and the deduced amino acid sequence identities of ORFs 1-3 were 99.8, 100 and 100 %, respectively. The high degree of genomic similarity observed between swine and human HEV isolates in a restricted area of Japan further supports the finding that sporadic hepatitis E in Japan is a zoonosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1317
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1245-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12692290-Amino Acid Sequence,
pubmed-meshheading:12692290-Animals,
pubmed-meshheading:12692290-Base Sequence,
pubmed-meshheading:12692290-Genome, Viral,
pubmed-meshheading:12692290-Genotype,
pubmed-meshheading:12692290-Hepatitis, Viral, Animal,
pubmed-meshheading:12692290-Hepatitis E,
pubmed-meshheading:12692290-Hepatitis E virus,
pubmed-meshheading:12692290-Humans,
pubmed-meshheading:12692290-Japan,
pubmed-meshheading:12692290-Middle Aged,
pubmed-meshheading:12692290-Molecular Sequence Data,
pubmed-meshheading:12692290-Phylogeny,
pubmed-meshheading:12692290-Sequence Analysis, DNA,
pubmed-meshheading:12692290-Swine,
pubmed-meshheading:12692290-Swine Diseases,
pubmed-meshheading:12692290-Zoonoses
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pubmed:year |
2003
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pubmed:articleTitle |
Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99 % identity over the entire genome.
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pubmed:affiliation |
Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi-Ken 329-0498, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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