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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-14
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pubmed:abstractText |
The t(2;5) translocation results in a 80-kDa oncogenic fusion protein consisting of NPM and the kinase domain of the tyrosine kinase ALK and is present in over half the cases of anaplastic large cell lymphoma (ALCL). NPM/ALK exerts its transforming potential via activation of multiple signaling pathways promoting growth factor independence and protection from apoptosis. Jak/Stat signaling is aberrantly activated in several human hematopoietic malignancies. We investigated the role of Jak2 in the context of NPM/ALK-mediated oncogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caseins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyano-(3,4-dihydroxy)-N-benzyl...,
http://linkedlifedata.com/resource/pubmed/chemical/p80(NPM-ALK) protein
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-15
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12691918-Animals,
pubmed-meshheading:12691918-Apoptosis,
pubmed-meshheading:12691918-B-Lymphocytes,
pubmed-meshheading:12691918-Caseins,
pubmed-meshheading:12691918-Cell Division,
pubmed-meshheading:12691918-Cell Line, Transformed,
pubmed-meshheading:12691918-Cell Transformation, Neoplastic,
pubmed-meshheading:12691918-DNA-Binding Proteins,
pubmed-meshheading:12691918-Enzyme Activation,
pubmed-meshheading:12691918-Enzyme Inhibitors,
pubmed-meshheading:12691918-Gene Expression,
pubmed-meshheading:12691918-Hematopoietic Stem Cells,
pubmed-meshheading:12691918-Immunosorbent Techniques,
pubmed-meshheading:12691918-Janus Kinase 2,
pubmed-meshheading:12691918-Luciferases,
pubmed-meshheading:12691918-Mice,
pubmed-meshheading:12691918-Milk Proteins,
pubmed-meshheading:12691918-Phosphorylation,
pubmed-meshheading:12691918-Phosphotyrosine,
pubmed-meshheading:12691918-Promoter Regions, Genetic,
pubmed-meshheading:12691918-Protein-Tyrosine Kinases,
pubmed-meshheading:12691918-Proto-Oncogene Proteins,
pubmed-meshheading:12691918-STAT5 Transcription Factor,
pubmed-meshheading:12691918-Trans-Activators,
pubmed-meshheading:12691918-Transcription, Genetic,
pubmed-meshheading:12691918-Transfection,
pubmed-meshheading:12691918-Tyrphostins
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pubmed:year |
2003
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pubmed:articleTitle |
Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.
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pubmed:affiliation |
The National Cancer Institute, Oncogenic Fusion Proteins Unit, Department of Experimental Oncology, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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