Source:http://linkedlifedata.com/resource/pubmed/id/12691525
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-4-14
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| pubmed:abstractText |
The expression and activity of 8-oxoguanosine DNA-glycosylase (Ogg1), a key enzyme responsible forthe clearance of the oxidized DNA base 8-hydroxy-2'-deoxyguanosine (oxo8dG), was determined in the cerebellum (CB) and the caudate and the putamen (CP) of male Balb/c, ICR, and C57BL/J mice. There was no significant difference in the protein expression of Ogg1 in the CB or CP. The activity of Ogg1 was not significantly different in the CB; however, in the CP of ICR mice, the activity of Ogg1 was 34% and 31% lower than Balb/c and C57BL/J, respectively. In contrast, the levels of oxo8dG in the CB and CP of C57BL/J mice were nearly twice as high as the values in both regions of Balb/c and ICR mice. The activity of superoxide dismutases (SOD) appeared to account for the differences in the levels of oxo8dG in the C57BL/J strain. Total SOD in the C57BL/J strain was two- and fourfold higher in the CB and CP, respectively, versus the other strains. These results suggest that the enhanced vulnerability of the C57BL/J strain to neurotoxicants may not be due to a decreased capacity for DNA repair, but rather, the significantly higher activity of SODs, which may cause these pathways to become more readily saturated.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxy-2'-deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Formamidopyrimidine Glycosylase,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1052-2166
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
47-53
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12691525-Animals,
pubmed-meshheading:12691525-Brain,
pubmed-meshheading:12691525-DNA Damage,
pubmed-meshheading:12691525-DNA Repair,
pubmed-meshheading:12691525-DNA-Formamidopyrimidine Glycosylase,
pubmed-meshheading:12691525-Deoxyguanosine,
pubmed-meshheading:12691525-Drug Tolerance,
pubmed-meshheading:12691525-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12691525-Genetic Predisposition to Disease,
pubmed-meshheading:12691525-Male,
pubmed-meshheading:12691525-Mice,
pubmed-meshheading:12691525-Mice, Inbred BALB C,
pubmed-meshheading:12691525-Mice, Inbred C57BL,
pubmed-meshheading:12691525-Mice, Inbred ICR,
pubmed-meshheading:12691525-Neurodegenerative Diseases,
pubmed-meshheading:12691525-Neurons,
pubmed-meshheading:12691525-Neurotoxins,
pubmed-meshheading:12691525-Species Specificity,
pubmed-meshheading:12691525-Superoxide Dismutase
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| pubmed:year |
2003
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| pubmed:articleTitle |
Strain-specific differences in the expression and activity of Ogg1 in the CNS.
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| pubmed:affiliation |
Department of Neurology, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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