Source:http://linkedlifedata.com/resource/pubmed/id/12691153
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-4-14
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| pubmed:abstractText |
The association of Non-Hodgkin Lymphoma (NHL) and HIV-infection was soon recognized and the Center of Disease Control (CDC) has classified some types of NHL as AIDS-defining illnesses (ADI). Hodgkin's disease (HD) represents the most common type of non ADI malignancy in HIV-infected cases. Commonly, data on malignant lymphoma in this population is collected in known HIV-positive patients or in autopsy-series. This registration study was designed to estimate the incidence of HIV-positivity in patients with newly diagnosed malignant lymphoma. A registration of all patients with newly diagnosed malignant lymphoma and their HIV-status was performed in every center of the Swiss Group for Clinical Cancer research (SAKK) from January 1, 1991 to July 31, 1993. Among 474 eligible patients, HIV-status was evaluated in 400 and 52 were tested positive (13%), 42 (81%) of them males. Three of them were newly detected cases (after lymphoma-diagnosis). Three hundred and forty patients (72%) presented with NHL, 42 (12.4%) of them HIV-positive; 33 out of these had aggressive lymphoma. B-symptoms were significantly more frequent in HIV-positive patients. In the 134 patients with HD, 10 (7.5%) tested HIV-positive, mostly presenting with stage IV disease (7), B-symptoms (9) and extranodal disease (7). In conclusion, 13% out of 400 evaluated patients with newly diagnosed malignant lymphoma tested HIV-positive. The study confirms the predominance of aggressive lymphoma histologies and frequent presentation with B-symptoms in HIV-positive patients with NHL. Male gender, young age (26-35 years) and B-symptoms are prognostic factors for HIV-positivity in NHL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1042-8194
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| pubmed:author |
pubmed-author:CavalliFrancoF,
pubmed-author:CernyThomasT,
pubmed-author:D'AddarioGiannicolaG,
pubmed-author:DieterleAlexanderA,
pubmed-author:EgliFritzF,
pubmed-author:FeyMartinM,
pubmed-author:KettererNicolasN,
pubmed-author:LohriAndreasA,
pubmed-author:MaibachRudolfR,
pubmed-author:StahelRolfR,
pubmed-author:TorhorstJoachimJ
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| pubmed:issnType |
Print
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
133-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12691153-Adolescent,
pubmed-meshheading:12691153-Adult,
pubmed-meshheading:12691153-Aged,
pubmed-meshheading:12691153-Female,
pubmed-meshheading:12691153-HIV Infections,
pubmed-meshheading:12691153-Hodgkin Disease,
pubmed-meshheading:12691153-Humans,
pubmed-meshheading:12691153-Incidence,
pubmed-meshheading:12691153-Lymphoma,
pubmed-meshheading:12691153-Lymphoma, AIDS-Related,
pubmed-meshheading:12691153-Lymphoma, Non-Hodgkin,
pubmed-meshheading:12691153-Male,
pubmed-meshheading:12691153-Middle Aged,
pubmed-meshheading:12691153-Odds Ratio,
pubmed-meshheading:12691153-Prognosis,
pubmed-meshheading:12691153-Registries,
pubmed-meshheading:12691153-Risk Factors,
pubmed-meshheading:12691153-Switzerland
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| pubmed:year |
2003
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| pubmed:articleTitle |
HIV-testing and newly-diagnosed malignant lymphomas. The SAKK 96/90 registration study.
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| pubmed:affiliation |
Fachbereich Onkologie-Hämatologie, Kantonsspital, CH-9007 St. Gallen, Switzerland.
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| pubmed:publicationType |
Journal Article
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