Source:http://linkedlifedata.com/resource/pubmed/id/12691152
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2003-4-14
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pubmed:abstractText |
Mutations in the BRCA1 and BRCA2 tumor suppressor genes are associated with an increased risk for breast and ovarian cancers as well as other types of malignancies. The observation of a germline BRCA1 mutation in an index case with a lymphoid neoplasm in the setting of a family history of breast cancer prompted us to explore the role of BRCA germline mutations as lymphoma susceptibility alleles. A panel of 286 DNA samples from Jewish lymphoma patients was analyzed for the three most frequent BRCA1 and BRCA2 germline mutations in those of Ashkenazi Jewish heritage, and compared to a cohort of 5010 DNA samples from healthy controls. Of the 286 cases, 2 patients carried a germline BRCA mutation; both were diagnosed at an early age with an intermediate grade non-Hodgkin's lymphoma. This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1042-8194
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12691152-Adult,
pubmed-meshheading:12691152-Age Distribution,
pubmed-meshheading:12691152-Aged,
pubmed-meshheading:12691152-BRCA1 Protein,
pubmed-meshheading:12691152-BRCA2 Protein,
pubmed-meshheading:12691152-Breast Neoplasms,
pubmed-meshheading:12691152-Case-Control Studies,
pubmed-meshheading:12691152-DNA Mutational Analysis,
pubmed-meshheading:12691152-Family Health,
pubmed-meshheading:12691152-Female,
pubmed-meshheading:12691152-Gene Frequency,
pubmed-meshheading:12691152-Germ-Line Mutation,
pubmed-meshheading:12691152-Humans,
pubmed-meshheading:12691152-Jews,
pubmed-meshheading:12691152-Lymphoma,
pubmed-meshheading:12691152-Male,
pubmed-meshheading:12691152-Middle Aged,
pubmed-meshheading:12691152-Pedigree
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pubmed:year |
2003
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pubmed:articleTitle |
BRCA1 and BRCA2 germline mutations in lymphoma patients.
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pubmed:affiliation |
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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