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rdf:type |
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lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205178,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1552861,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
5617
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pubmed:dateCreated |
2003-4-11
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pubmed:abstractText |
The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-10510340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-10899025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-11000251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-11721060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-11861602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-11877489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-11907108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12209632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12242444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12414983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12507420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12538706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12594515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-12690179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-1832488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-7726898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-7911534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-7966595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-8551565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-9624003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-9624004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-9624005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-9722921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-9858506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12690202-9858507
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-42
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:12690202-Adoptive Transfer,
pubmed-meshheading:12690202-Animals,
pubmed-meshheading:12690202-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12690202-Cytotoxicity, Immunologic,
pubmed-meshheading:12690202-Genes, MHC Class II,
pubmed-meshheading:12690202-Immunization,
pubmed-meshheading:12690202-Immunologic Memory,
pubmed-meshheading:12690202-Interferon-gamma,
pubmed-meshheading:12690202-Listeria monocytogenes,
pubmed-meshheading:12690202-Listeriosis,
pubmed-meshheading:12690202-Mice,
pubmed-meshheading:12690202-Mice, Inbred C57BL,
pubmed-meshheading:12690202-Ovalbumin,
pubmed-meshheading:12690202-T-Lymphocyte Subsets,
pubmed-meshheading:12690202-T-Lymphocytes, Helper-Inducer
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pubmed:year |
2003
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pubmed:articleTitle |
Defective CD8 T cell memory following acute infection without CD4 T cell help.
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pubmed:affiliation |
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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