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pubmed-article:12689549pubmed:abstractTextThe etiology of neural tube defects (NTDs) is multifactorial. The presence of mutated genotypes of C677T and A1298C polymorphisms, and their combined heterozygosity, have been considered risk factors for the occurrence and recurrence of NTDs in some populations. Subjects and method: This case-control study included 159 healthy controls, 27 NTDs patients, 28 patients' mothers and 23 siblings. The polymorphism study was performed by PCR. For fragment digestion, we used the restriction enzymes Hinf I (C677T) and Mbo II (A1298C).lld:pubmed
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pubmed-article:12689549pubmed:pagination441-5lld:pubmed
pubmed-article:12689549pubmed:dateRevised2009-11-3lld:pubmed
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pubmed-article:12689549pubmed:year2003lld:pubmed
pubmed-article:12689549pubmed:articleTitle[C677T and A1298C MTHFR polymorphisms in the etiology of neural tube defects in Spanish population].lld:pubmed
pubmed-article:12689549pubmed:affiliationSección de Genética. Servicio de Bioquímica Clínica. Hospital Universitario Miguel Servet. Zaragoza. España. joseignaciogutierrez@redfarma.orglld:pubmed
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