Source:http://linkedlifedata.com/resource/pubmed/id/12688341
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-4-11
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| pubmed:abstractText |
Interleukin-10 (IL-10) is mainly an anti-inflammatory cytokine produced by a number of cells including normal and neoplastic B cells. It has been implicated in autoimmunity, transplantation tolerance and tumourigenesis. Polymorphisms in the IL-10 gene promoter genetically determine inter-individual differences in IL-10 production. The aim of this study was to determine whether polymorphisms in the IL-10 gene promoter play a role in predisposing an individual to lymphoma. We analysed the frequencies of three single base substitutions in the IL-10 promoter in patients with aggressive lymphoma (B-cell DLCL n = 46, other aggressive histologies n = 17), Hodgkin's disease (n = 44) or low/intermediate grade lymphoma (n = 46), compared to healthy controls. The frequency of the low-IL-10 producing AA allele (at position -1082) was significantly higher in patients with aggressive lymphoma compared to controls (p = 0.0344, Odds ratio 1.974, 95% C.I 1.066-3.655). Similarly, the frequency of the low IL-10 producing ATA or the intermediate-IL-10- producing ACC haplotype was significantly higher in patients with aggressive disease compared to controls (p = 0.0255, Odds ratio 1.647, 95% C.I 1.077-2.518). No association was found between IL-10 genotypes and Hodgkin's disease or less aggressive forms of lymphoma. Thus, polymorphisms in the IL-10 gene promoter which are associated with a low IL-10 producing phenotype may influence susceptibility to aggressive forms of lymphoma or may contribute to the pathogenesis of this disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1042-8194
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
251-5
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12688341-Case-Control Studies,
pubmed-meshheading:12688341-Gene Frequency,
pubmed-meshheading:12688341-Genetic Predisposition to Disease,
pubmed-meshheading:12688341-Genotype,
pubmed-meshheading:12688341-Haplotypes,
pubmed-meshheading:12688341-Hodgkin Disease,
pubmed-meshheading:12688341-Humans,
pubmed-meshheading:12688341-Interleukin-10,
pubmed-meshheading:12688341-Lymphoma, Non-Hodgkin,
pubmed-meshheading:12688341-Polymerase Chain Reaction,
pubmed-meshheading:12688341-Polymorphism, Genetic,
pubmed-meshheading:12688341-Promoter Regions, Genetic
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Polymorphisms in the interleukin 10 gene promoter are associated with susceptibility to aggressive non-Hodgkin's lymphoma.
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| pubmed:affiliation |
The Western Australian Centre for Pathology and Medical Research, Perth, WA, Australia.
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| pubmed:publicationType |
Journal Article
|