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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-4-10
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pubmed:abstractText |
Recent success in islet transplantation renews the hope for the complete cure of patients afflicted with Type 1 diabetes. However, in the Edmonton series, two to four pancreas donors were required to obtain a sufficient islet mass to reverse the diabetes of each patient. In view of the donor shortage, this represents a major obstacle preventing greater application of islet transplantation to diabetic patients. We hypothesised that increasing the expression of the insulin gene in transplanted islets would augment their capacity for insulin production, thereby allowing reversal of diabetes with a reduced islet mass.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-93
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12687337-Adenoviridae,
pubmed-meshheading:12687337-Animals,
pubmed-meshheading:12687337-Blood Glucose,
pubmed-meshheading:12687337-Gene Expression Regulation,
pubmed-meshheading:12687337-Gene Transfer Techniques,
pubmed-meshheading:12687337-Glucagon,
pubmed-meshheading:12687337-Humans,
pubmed-meshheading:12687337-Insulin,
pubmed-meshheading:12687337-Islets of Langerhans,
pubmed-meshheading:12687337-Islets of Langerhans Transplantation,
pubmed-meshheading:12687337-Lac Operon,
pubmed-meshheading:12687337-Mice,
pubmed-meshheading:12687337-Mice, Inbred NOD,
pubmed-meshheading:12687337-Mice, SCID,
pubmed-meshheading:12687337-Microscopy, Electron,
pubmed-meshheading:12687337-Proinsulin,
pubmed-meshheading:12687337-Promoter Regions, Genetic,
pubmed-meshheading:12687337-Subcellular Fractions,
pubmed-meshheading:12687337-Transgenes,
pubmed-meshheading:12687337-Transplantation, Heterologous
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pubmed:year |
2003
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pubmed:articleTitle |
Insulin gene transfer enhances the function of human islet grafts.
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pubmed:affiliation |
The Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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