Linked Life Data

12686700

Source:http://linkedlifedata.com/resource/pubmed/id/12686700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2003-4-10
pubmed:abstractText
One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences. Because this form is resistant to multiple antiepileptic drugs, the mode of resistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1 and P-glycoprotein 170). We hypothesized that the CC genotype at the ABCB1 C3435T polymorphism, which is associated with increased expression of the protein, influences the response to antiepileptic-drug treatment.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1533-4406
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Massachusetts Medical Society
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
348
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1442-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
pubmed:affiliation
Department of Molecular Pathogenesis, Institute of Neurology, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't