12686527

Source:http://linkedlifedata.com/resource/pubmed/id/12686527

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0027662, umls-concept:C0220825, umls-concept:C0332307, umls-concept:C0439849
pubmed:issue	4
pubmed:dateCreated	2003-4-10
pubmed:abstractText	Multiple endocrine neoplasia type 2 (MEN 2) is caused by RET proto-oncogene mutations and has a strong penetrance for medullary thyroid carcinoma (MTC). Subtypes are defined by the presence or absence of pheochromocytomas, hyperparathyroidism, and characteristic clinical stigmas. We hypothesize that specific RET mutations correlate with the MEN 2 phenotype and aggressiveness of MTC.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9716528
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret, http://linkedlifedata.com/resource/pubmed/chemical/RET protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0004-0010
pubmed:author	pubmed-author:AyersGregory DGD, pubmed-author:CoteGilbert JGJ, pubmed-author:EvansDouglas BDB, pubmed-author:GagelRobert FRF, pubmed-author:HerzogCynthia ECE, pubmed-author:LeeJeffrey EJE, pubmed-author:SellinRena VRV, pubmed-author:ShapiroSuzanne ESE, pubmed-author:ShermanSteven ISI, pubmed-author:YipLinwahL
pubmed:issnType	Print
pubmed:volume	138
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	409-16; discussion 416
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:12686527-Adolescent, pubmed-meshheading:12686527-Adult, pubmed-meshheading:12686527-Child, pubmed-meshheading:12686527-Child, Preschool, pubmed-meshheading:12686527-Follow-Up Studies, pubmed-meshheading:12686527-Genotype, pubmed-meshheading:12686527-Humans, pubmed-meshheading:12686527-Middle Aged, pubmed-meshheading:12686527-Multiple Endocrine Neoplasia Type 2a, pubmed-meshheading:12686527-Multiple Endocrine Neoplasia Type 2b, pubmed-meshheading:12686527-Multivariate Analysis, pubmed-meshheading:12686527-Mutation, pubmed-meshheading:12686527-Oncogene Proteins, pubmed-meshheading:12686527-Phenotype, pubmed-meshheading:12686527-Proto-Oncogene Proteins c-ret, pubmed-meshheading:12686527-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:12686527-Thyroid Neoplasms, pubmed-meshheading:12686527-Thyroidectomy
pubmed:year	2003
pubmed:articleTitle	Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship.
pubmed:affiliation	Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
pubmed:publicationType	Journal Article