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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-4-10
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pubmed:abstractText |
The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
341
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12686390-Animals,
pubmed-meshheading:12686390-Animals, Newborn,
pubmed-meshheading:12686390-Cerebral Cortex,
pubmed-meshheading:12686390-Choline,
pubmed-meshheading:12686390-Choline Deficiency,
pubmed-meshheading:12686390-Diet,
pubmed-meshheading:12686390-Dizocilpine Maleate,
pubmed-meshheading:12686390-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12686390-Female,
pubmed-meshheading:12686390-Gyrus Cinguli,
pubmed-meshheading:12686390-Neurons,
pubmed-meshheading:12686390-Nootropic Agents,
pubmed-meshheading:12686390-Pregnancy,
pubmed-meshheading:12686390-Prenatal Exposure Delayed Effects,
pubmed-meshheading:12686390-Rats,
pubmed-meshheading:12686390-Rats, Sprague-Dawley
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pubmed:year |
2003
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pubmed:articleTitle |
Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.
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pubmed:affiliation |
Neurobiology Research Laboratory, VA Medical Center, 27705, Durham, NC, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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