Linked Life Data

12684883

Source:http://linkedlifedata.com/resource/pubmed/id/12684883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-7-28
pubmed:abstractText
In the present study, we investigated the in vitro effects on the motility and morphology of tissues and organs of Toxocara canis of the two drug components of Drontal Plus and Welpan, pyrantel and fenbendazole (the active metabolite of the prodrug febantel), both alone and in combination. Although there was no significant difference observable between the effects of the single drugs and the drug combination on worm motility, the synergistic effect of pyrantel and fenbendazole was manifested by morphological alterations seen by light and electron microscopy. Thus, an earlier onset of damage to worm tissues and organs could be observed compared to the application of the individual drugs. In addition, a higher degree of damage and an increased number of vital organs were involved. There was dramatic, significantly greater and irreversible damage to the hypodermis, longitudinal muscle, intestine, nerve cords and genital organs induced by the pyrantel/fenbendazole combination. We hypothesise that these synergistic effects will also take place when dogs are treated either with Drontal Plus or Welpan in which lower dosages will be sufficient to destroy the worms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0932-0113
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-13
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
A light and electron microscopic study on the synergistic effect of pyrantel and the febantel metabolite febendazole on adult Toxocara canis in vitro.
pubmed:affiliation
Institute of Zoomorphology, Cell Biology and Parasitology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany. mehlhorn@uni-duesseldorf.de
pubmed:publicationType
Journal Article