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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-14
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pubmed:abstractText |
To test the hypothesis that estrogens alter insulin action, we evaluated the effects of intravenous conjugated estrogens (CE) on insulin-stimulated steady-state glucose infusion rate (SSGIR) and suppression of plasma glycerol in postmenopausal women (mean +/- SD; 56 +/- 4 yr; n = 12) not using hormone replacement. SSGIR and glycerol were measured during a two-stage (8 and 40 mU. m-2. min-1) hyperinsulinemic euglycemic clamp on 2 days, with or without a 2.5-mg intravenous CE bolus. Serum estradiol concentrations were increased approximately 200% on the estrogen (EST) compared with the control (CON) days. Serum insulin was reduced (P < 0.01) during stage 2 of the clamp for EST (63.3 +/- 12.8 micro U/ml) vs. CON (78.2 +/- 15.8 micro U/ml). Mean SSGIR and plasma glycerol did not differ between CON and EST days. With adjustment for differences in insulin concentration between conditions, stage 2 glucose disposals were significantly higher (8.63 vs. 7.20 mg. kg-1. min-1) and plasma glycerol concentrations were significantly lower (29.4 vs. 35.0 micro mol/l) for EST vs. CON. Our findings suggest that acute CE administration increases insulin clearance and action in postmenopausal women.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12684221-10071420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12684221-10094109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12684221-10100178,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12684221-9773716
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0193-1849
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
285
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E311-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12684221-Body Composition,
pubmed-meshheading:12684221-Estradiol,
pubmed-meshheading:12684221-Estrogens, Conjugated (USP),
pubmed-meshheading:12684221-Female,
pubmed-meshheading:12684221-Glucose,
pubmed-meshheading:12684221-Glucose Clamp Technique,
pubmed-meshheading:12684221-Glycerol,
pubmed-meshheading:12684221-Humans,
pubmed-meshheading:12684221-Hyperinsulinism,
pubmed-meshheading:12684221-Injections, Intravenous,
pubmed-meshheading:12684221-Insulin,
pubmed-meshheading:12684221-Kinetics,
pubmed-meshheading:12684221-Middle Aged,
pubmed-meshheading:12684221-Postmenopause
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pubmed:year |
2003
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