Source:http://linkedlifedata.com/resource/pubmed/id/12682220
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2003-4-8
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| pubmed:abstractText |
CD4(+)CD25(+) regulatory T cells have been shown to prevent T cell-mediated immune pathology; however, their ability to ameliorate established inflammation has not been tested. Using the CD4(+)CD45RB(high) T cell transfer model of inflammatory bowel disease, we show that CD4(+)CD25(+) but not CD4(+)CD25(-)CD45RB(low) T cells are able to cure intestinal inflammation. Transfer of CD4(+)CD25(+) T cells into mice with colitis led to resolution of the lamina propria infiltrate in the intestine and reappearance of normal intestinal architecture. CD4(+)CD25(+) T cells were found to proliferate in the mesenteric lymph nodes and inflamed colon. They were located between clusters of CD11c(+) cells and pathogenic T cells and found to be in contact with both cell types. These studies suggest that manipulation of CD4(+)CD25(+) T cells may be beneficial in the treatment of chronic inflammatory diseases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
170
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3939-43
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12682220-Adoptive Transfer,
pubmed-meshheading:12682220-Animals,
pubmed-meshheading:12682220-Antigens, CD11c,
pubmed-meshheading:12682220-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12682220-Cell Communication,
pubmed-meshheading:12682220-Cell Division,
pubmed-meshheading:12682220-Cell Movement,
pubmed-meshheading:12682220-Colitis,
pubmed-meshheading:12682220-Colon,
pubmed-meshheading:12682220-Lymph Nodes,
pubmed-meshheading:12682220-Mesentery,
pubmed-meshheading:12682220-Mice,
pubmed-meshheading:12682220-Mice, Inbred BALB C,
pubmed-meshheading:12682220-Mice, Inbred C57BL,
pubmed-meshheading:12682220-Mice, Knockout,
pubmed-meshheading:12682220-Mice, SCID,
pubmed-meshheading:12682220-Receptors, Interleukin-2,
pubmed-meshheading:12682220-T-Lymphocyte Subsets,
pubmed-meshheading:12682220-Wasting Syndrome
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells.
|
| pubmed:affiliation |
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|