Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-4-8
pubmed:abstractText
Although a large number of studies have been carried out on the diverse effects mediated by the common neurotrophin receptor p75(NTR), little is known about the molecular mechanisms by which p75(NTR) initiates intracellular signal transduction. We identified a variant of the beta catalytic subunit of cAMP-dependent protein kinase (PKACbeta) as a p75(NTR)-interacting protein, which phosphorylates p75(NTR) at Ser304. Intracellular cAMP in cerebellar neurons was accumulated transiently by ligand binding to p75(NTR). Activation of cAMP-PKA is required for translocation of p75(NTR) to lipid rafts, and for biochemical and biological activities of p75(NTR), such as inactivation of Rho and the neurite outgrowth. Proper recruitment of activated p75(NTR) to lipid rafts, structures that represent specialized signaling organelles, is of fundamental importance in determining p75(NTR) bioactivity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10027292, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10375560, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10473574, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10493721, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10595511, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10606727, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10774729, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10805756, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-10851172, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11027232, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11179879, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11211234, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11287428, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11312266, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11425900, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11432870, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11502760, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11525727, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11589697, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-11756498, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-12011108, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-12036959, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-12388596, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-194899, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-2989274, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-3020030, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-3028414, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-7519025, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-7522484, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-7524558, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-7685294, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8079174, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8146193, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8599934, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8614802, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8702878, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8878481, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-8982258, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9099750, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9151756, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9154808, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9177342, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9230436, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9368018, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9535903, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9852160, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9927417, http://linkedlifedata.com/resource/pubmed/commentcorrection/12682012-9927421
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1790-800
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:12682012-Amino Acid Sequence, pubmed-meshheading:12682012-Animals, pubmed-meshheading:12682012-Brain-Derived Neurotrophic Factor, pubmed-meshheading:12682012-Cells, Cultured, pubmed-meshheading:12682012-Cyclic AMP, pubmed-meshheading:12682012-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:12682012-Humans, pubmed-meshheading:12682012-Membrane Microdomains, pubmed-meshheading:12682012-Molecular Sequence Data, pubmed-meshheading:12682012-Nerve Growth Factor, pubmed-meshheading:12682012-Neurons, pubmed-meshheading:12682012-Phosphorylation, pubmed-meshheading:12682012-Receptor, Nerve Growth Factor, pubmed-meshheading:12682012-Receptors, Nerve Growth Factor, pubmed-meshheading:12682012-Signal Transduction, pubmed-meshheading:12682012-Tissue Distribution, pubmed-meshheading:12682012-Two-Hybrid System Techniques
pubmed:year
2003
pubmed:articleTitle
PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.
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