| pubmed-article:12681287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C0812281 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C1517341 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C1510779 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C0027303 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:12681287 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12681287 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12681287 | pubmed:dateCreated | 2003-4-8 | lld:pubmed |
| pubmed-article:12681287 | pubmed:abstractText | In this work, we report that type IV collagen, mainly via alpha2beta1-integrin ligation, was able to induce cyclin expression and G1/S transition in a colic adenocarcinoma cell line (Caco-2) cultured without soluble growth factors or fetal bovine serum. This process involved Erk 1/2 activation and the production of reactive oxygen species (ROS) by a membrane-bound NADPH oxidase. Data presented here show that NADPH oxidase-dependent production of ROS increased following alpha2beta1-integrin ligation with type IV collagen or with a specific monoclonal antibody (Gi9 mAb). NADPH oxidase activation and, therefore, the production of ROS were shown to be involved in the increase of alpha2beta1-integrin plasma membrane expression, p38 MAPK phosphorylation, cyclin expression, and G1/S transition. We thus identified in this work a new integrin-signaling pathway in colon tumor cells involved in cell cycle regulation by the extracellular matrix. | lld:pubmed |
| pubmed-article:12681287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12681287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12681287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12681287 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12681287 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:12681287 | pubmed:author | pubmed-author:BriandClaudet... | lld:pubmed |
| pubmed-article:12681287 | pubmed:author | pubmed-author:PichardVéroni... | lld:pubmed |
| pubmed-article:12681287 | pubmed:author | pubmed-author:RognoniJean-B... | lld:pubmed |
| pubmed-article:12681287 | pubmed:author | pubmed-author:KovacicHervéH | lld:pubmed |
| pubmed-article:12681287 | pubmed:author | pubmed-author:HonoréStéphan... | lld:pubmed |
| pubmed-article:12681287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12681287 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12681287 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:12681287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12681287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12681287 | pubmed:pagination | 59-71 | lld:pubmed |
| pubmed-article:12681287 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:meshHeading | pubmed-meshheading:12681287... | lld:pubmed |
| pubmed-article:12681287 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12681287 | pubmed:articleTitle | Alpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS. | lld:pubmed |
| pubmed-article:12681287 | pubmed:affiliation | UMR-CNRS 6032, Faculté de Pharmacie, Université de la Méditerranée, 27, Bd Jean Moulin 13385 05, Marseille Cedex, France. stephane.honore@pharmacie.univ-mrs.fr | lld:pubmed |
| pubmed-article:12681287 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:3688 | entrezgene:pubmed | pubmed-article:12681287 | lld:entrezgene |
| entrez-gene:3673 | entrezgene:pubmed | pubmed-article:12681287 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12681287 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12681287 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12681287 | lld:pubmed |
