Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1976-8-2
|
pubmed:abstractText |
Chloramphenicol (CAP), an antibiotic which causes various blood dyscrasias, was shown to inhibit in vitro protein synthesis of human blood platelets. The effect is dose- and time-dependent, it is reversible after incubation for 2 h, and is comparable with the suppression achieved by cycloheximide (CXM). Electron microscopic examination revealed swelling and destruction of mitochondria. Administration of CAP to dogs produced a progressive inhibition of platelet protein synthesis as shown by a reduction in the rate of [3H]leucine incorporation into protein. The maximal inhibitory effect of the antibiotic was reached 0.5-4.0 h after its administration, when minimal leucine incorporation values of 9-40% of the control were measured. The suppressive effect of CAP was followed by an overshoot in the incorporation of [3H]leucine, up to a maximum of 602% of the value at zero time of the experiment.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0007-1048
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
33
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
53-9
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:1268090-Animals,
pubmed-meshheading:1268090-Blood Platelets,
pubmed-meshheading:1268090-Chloramphenicol,
pubmed-meshheading:1268090-Dogs,
pubmed-meshheading:1268090-Humans,
pubmed-meshheading:1268090-Leucine,
pubmed-meshheading:1268090-Protein Biosynthesis,
pubmed-meshheading:1268090-Tritium
|
pubmed:year |
1976
|
pubmed:articleTitle |
Chloramphenicol induced inhibition of platelet protein synthesis: in vitro and in vivo studies.
|
pubmed:publicationType |
Journal Article
|