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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1A
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pubmed:dateCreated |
2003-4-8
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pubmed:abstractText |
Monoclonality, a hallmark of most neoplasias, is found in high-grade squamous intraepithelial lesions (Hi-SIL) and some low-grade SILs (Lo-SIL). The transforming genes E6/E7 of HPV 16 have been shown to induce telomerase activity and immortalization. We investigated the role of immortalization in monoclonal and polyclonal SILs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/E6 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Papillomavirus E7 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase,
http://linkedlifedata.com/resource/pubmed/chemical/oncogene protein E7, Human...
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12680207-Cell Transformation, Viral,
pubmed-meshheading:12680207-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:12680207-Clone Cells,
pubmed-meshheading:12680207-DNA, Viral,
pubmed-meshheading:12680207-Female,
pubmed-meshheading:12680207-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12680207-Gene Expression Regulation, Viral,
pubmed-meshheading:12680207-Genes, Viral,
pubmed-meshheading:12680207-Humans,
pubmed-meshheading:12680207-In Situ Hybridization,
pubmed-meshheading:12680207-Oncogene Proteins, Viral,
pubmed-meshheading:12680207-Papillomaviridae,
pubmed-meshheading:12680207-Papillomavirus E7 Proteins,
pubmed-meshheading:12680207-Polymerase Chain Reaction,
pubmed-meshheading:12680207-RNA, Neoplasm,
pubmed-meshheading:12680207-Repressor Proteins,
pubmed-meshheading:12680207-Telomerase,
pubmed-meshheading:12680207-Up-Regulation,
pubmed-meshheading:12680207-Uterine Cervical Neoplasms
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pubmed:articleTitle |
Clonal expansion and HPV-induced immortalization are early molecular alterations in cervical carcinogenesis.
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pubmed:affiliation |
Department of Obstetrics and Gynaecology, University of Bonn, Bonn 53105. park@uke.uni-hamburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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