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pubmed-article:12680167pubmed:abstractTextThe interaction between paclitaxel and its target, beta tubulin, is essential for effective cytotoxicity. Alterations or mutation of beta tubulin have the potential to alter paclitaxel binding and confer a drug resistant phenotype.lld:pubmed
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pubmed-article:12680167pubmed:articleTitlebeta tubulin mutations are rare in human ovarian carcinoma.lld:pubmed
pubmed-article:12680167pubmed:affiliationDepartment of Hematology/Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.lld:pubmed
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