12680167

Source:http://linkedlifedata.com/resource/pubmed/id/12680167

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005290, umls-concept:C0026882, umls-concept:C0029925, umls-concept:C0086418, umls-concept:C0522498
pubmed:issue	1B
pubmed:dateCreated	2003-4-8
pubmed:abstractText	The interaction between paclitaxel and its target, beta tubulin, is essential for effective cytotoxicity. Alterations or mutation of beta tubulin have the potential to alter paclitaxel binding and confer a drug resistant phenotype.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8102988
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Carboplatin, http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel, http://linkedlifedata.com/resource/pubmed/chemical/Tubulin
pubmed:status	MEDLINE
pubmed:issn	0250-7005
pubmed:author	pubmed-author:DuanZhenfengZ, pubmed-author:LamendolaDiana EDE, pubmed-author:OlivaEstherE, pubmed-author:PensonRichard TRT, pubmed-author:SeidenMichael VMV
pubmed:issnType	Print
pubmed:volume	23
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	681-6
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:12680167-Adult, pubmed-meshheading:12680167-Aged, pubmed-meshheading:12680167-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:12680167-Carboplatin, pubmed-meshheading:12680167-Cisplatin, pubmed-meshheading:12680167-Combined Modality Therapy, pubmed-meshheading:12680167-DNA, Neoplasm, pubmed-meshheading:12680167-Exons, pubmed-meshheading:12680167-Female, pubmed-meshheading:12680167-Humans, pubmed-meshheading:12680167-Middle Aged, pubmed-meshheading:12680167-Ovarian Neoplasms, pubmed-meshheading:12680167-Paclitaxel, pubmed-meshheading:12680167-Point Mutation, pubmed-meshheading:12680167-Polymerase Chain Reaction, pubmed-meshheading:12680167-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:12680167-Retrospective Studies, pubmed-meshheading:12680167-Tubulin
pubmed:articleTitle	beta tubulin mutations are rare in human ovarian carcinoma.
pubmed:affiliation	Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't